not clinically validated; no atrial contraction, AV delay, inertance, closure regurgitation, valve area/FSI, septal/pericardial coupling, renal or drug models. Fixed cycles do not prove steady state. No Smith or published four-chamber reference reproduction. Sampled EDV/ESV/EF describe volume excursion; they need not equal ejection throughput during overlap or transients.
Trajectories · Summary · Semantic contract and provenance
{
"conservation": {
"local_balance_residual_ml": 1.7280399333685637e-11,
"total_initial_volume_ml": 5120.0,
"total_volume_drift_ml": 1.0913936421275139e-11
},
"limitations": "not clinically validated; no atrial contraction, AV delay, inertance, closure regurgitation, valve area/FSI, septal/pericardial coupling, renal or drug models. Fixed cycles do not prove steady state. No Smith or published four-chamber reference reproduction. Sampled EDV/ESV/EF describe volume excursion; they need not equal ejection throughput during overlap or transients.",
"metric_semantics": "SV/CO use integrated outlet flows; EDV/ESV/EF use sampled extrema. Pressure/volume means use sampled time quadrature.",
"metrics": {
"la_pressure_max_mmhg": 8.702371541802197,
"la_pressure_mean_mmhg": 6.658808584243309,
"la_pressure_min_mmhg": 5.462288217352229,
"la_volume_max_ml": 78.01581027868131,
"la_volume_mean_ml": 64.39205722828873,
"la_volume_min_ml": 56.41525478234819,
"lv_cardiac_output_l_min": 4.462357345370732,
"lv_cardiac_output_ml_s": 74.37262242284554,
"lv_edv_sample_ml": 109.0002411840834,
"lv_ejection_fraction_sample": 0.5458529017178426,
"lv_esv_sample_ml": 49.50214324580678,
"lv_stroke_volume_ml": 59.49809793827649,
"pa_pressure_max_mmhg": 23.202954816356296,
"pa_pressure_mean_mmhg": 17.814744502028745,
"pa_pressure_min_mmhg": 13.662900394985337,
"ra_pressure_max_mmhg": 4.954113078981488,
"ra_pressure_mean_mmhg": 3.5684377240919676,
"ra_pressure_min_mmhg": 2.8934821693472417,
"ra_volume_max_ml": 69.54113078981487,
"ra_volume_mean_ml": 55.684377240919666,
"ra_volume_min_ml": 48.934821693472415,
"rv_cardiac_output_l_min": 4.462377438210337,
"rv_cardiac_output_ml_s": 74.37295730350563,
"rv_edv_sample_ml": 98.79278981072407,
"rv_ejection_fraction_sample": 0.6022541316709119,
"rv_esv_sample_ml": 39.29442396791953,
"rv_stroke_volume_ml": 59.49836584280456,
"sa_pressure_max_mmhg": 98.83589515896088,
"sa_pressure_mean_mmhg": 81.6593524632826,
"sa_pressure_min_mmhg": 64.95807712812673
},
"model_id": "four_chamber_m1",
"model_version": "1.0.0",
"null_policy": "Unavailable periodicity for a single beat is null.",
"parameters": {
"compliance_pa": 5.0,
"compliance_pv": 20.0,
"compliance_sa": 1.5,
"compliance_sv": 100.0,
"elastance_la": 0.15,
"elastance_ra": 0.1,
"emax_lv": 2.5,
"emax_rv": 0.8,
"emin_lv": 0.06,
"emin_rv": 0.03,
"heart_rate": 75.0,
"initial_volumes": [
140.0,
850.0,
3200.0,
60.0,
140.0,
180.0,
490.0,
60.0
],
"resistance_aortic": 0.01,
"resistance_mitral": 0.01,
"resistance_pulmonary": 0.1,
"resistance_pulmonary_valve": 0.01,
"resistance_pulmonary_venous": 0.05,
"resistance_systemic": 1.0,
"resistance_tricuspid": 0.01,
"resistance_venous_return": 0.05,
"systolic_fraction": 0.4,
"unstressed_volumes": [
10.0,
700.0,
2500.0,
20.0,
10.0,
100.0,
400.0,
20.0
]
},
"periodicity": {
"interpretation": "Fixed cycle count does not prove steady state; sampled final/prior beat differences only.",
"max_difference_ml": 0.0007067402634675091,
"per_compartment_ml": {
"la": 6.79322103920299e-05,
"lv": 0.00024889087241319885,
"pa": 5.986735700957979e-05,
"pv": 0.00016198836647163262,
"ra": 4.872229416719165e-05,
"rv": 0.00010317636377976669,
"sa": 0.00044498443526208575,
"sv": 0.0007067402634675091
}
},
"pressure_reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
"provenance": "SYNTHETIC/EXPLORATORY test-design values; not literature-derived, not fitted, not normal physiology. Ventricular/vascular scalars reuse legacy exploratory defaults; new atrial and venous-inflow values are test-design choices. Explicit caller total: 5120 mL.",
"settings": {
"atol": 1e-10,
"max_step": 0.004,
"method": "DOP853",
"rtol": 1e-09
},
"simulation": {
"cycles": 30,
"samples_per_cycle": 400
}
}