{
  "run": {
    "config": {
      "parameters": {
        "compliance_pa": 5.0,
        "compliance_pv": 20.0,
        "compliance_sa": 1.5,
        "compliance_sv": 100.0,
        "elastance_la": 0.15,
        "elastance_ra": 0.1,
        "emax_lv": 2.5,
        "emax_rv": 0.8,
        "emin_lv": 0.06,
        "emin_rv": 0.03,
        "heart_rate": 75.0,
        "initial_volumes": [
          140.0,
          850.0,
          3200.0,
          60.0,
          140.0,
          180.0,
          490.0,
          60.0
        ],
        "resistance_aortic": 0.01,
        "resistance_mitral": 0.01,
        "resistance_pulmonary": 0.1,
        "resistance_pulmonary_valve": 0.01,
        "resistance_pulmonary_venous": 0.05,
        "resistance_systemic": 1.0,
        "resistance_tricuspid": 0.01,
        "resistance_venous_return": 0.05,
        "systolic_fraction": 0.4,
        "unstressed_volumes": [
          10.0,
          700.0,
          2500.0,
          20.0,
          10.0,
          100.0,
          400.0,
          20.0
        ]
      },
      "simulation": {
        "cycles": 30,
        "samples_per_cycle": 400
      },
      "solver": {
        "atol": 1e-10,
        "max_step": 0.004,
        "method": "DOP853",
        "rtol": 1e-09
      }
    },
    "config_sha256": "1dc412b19c1a36a17f650b8a2aaca60d04f96219051b9b4511b6b530917eb048",
    "dependencies": {
      "matplotlib": "3.11.2",
      "numpy": "2.4.6",
      "pint": "0.25.3",
      "scipy": "1.17.1"
    },
    "hash_scope": "All four output files other than manifest.json; manifest excludes its own hash.",
    "output_sha256": {
      "figure.png": "cf0e8d659513efc2561b5e95141019e237380f760232a5ba28c85bb47a8e789e",
      "index.html": "d9e2c729e9776571ac3e32a1311b2c6d3f246c8f44afc74c06e68bcf24685da5",
      "summary.json": "d465c183b031bbec747ef81f1ac45387a28e88ca7a9ac0acb3091e9939682e55",
      "trajectories.csv": "e853bab484597e61eb46e48766e7868142a7113317a6b8664eb394e9523f1d98"
    },
    "parameters": {
      "compliance_pa": 5.0,
      "compliance_pv": 20.0,
      "compliance_sa": 1.5,
      "compliance_sv": 100.0,
      "elastance_la": 0.15,
      "elastance_ra": 0.1,
      "emax_lv": 2.5,
      "emax_rv": 0.8,
      "emin_lv": 0.06,
      "emin_rv": 0.03,
      "heart_rate": 75.0,
      "initial_volumes": [
        140.0,
        850.0,
        3200.0,
        60.0,
        140.0,
        180.0,
        490.0,
        60.0
      ],
      "resistance_aortic": 0.01,
      "resistance_mitral": 0.01,
      "resistance_pulmonary": 0.1,
      "resistance_pulmonary_valve": 0.01,
      "resistance_pulmonary_venous": 0.05,
      "resistance_systemic": 1.0,
      "resistance_tricuspid": 0.01,
      "resistance_venous_return": 0.05,
      "systolic_fraction": 0.4,
      "unstressed_volumes": [
        10.0,
        700.0,
        2500.0,
        20.0,
        10.0,
        100.0,
        400.0,
        20.0
      ]
    },
    "python": "3.11.15 [build details redacted]",
    "replay_scope": "Same implementation and environment; no timestamps or stochastic input.",
    "settings": {
      "atol": 1e-10,
      "max_step": 0.004,
      "method": "DOP853",
      "rtol": 1e-09
    },
    "simulation": {
      "cycles": 30,
      "samples_per_cycle": 400
    },
    "source_hash_scope": "Package-relative observed runtime bytes; not proof of semantic or physiological validity.",
    "source_sha256": {
      "experiments/four_chamber_m1_demo.py": "a69c4ab485bcec60d8110bd37ec1e07e607f1708b0242d6596c37cec5a913dcd",
      "models/cardiovascular.py": "41be222561d553b93510448630c091c642f999b5be8f01ba65160f3a10ec3492",
      "models/four_chamber_m1.py": "5d7d68818554a7bf66772f7ca89eaeba76ce5daa31bc2198ed373617ec63c381",
      "ontology/anatomy_nodes_v2.json": "d5cdb5bbd883dc301493e2130399b199780c3f72faf640de1c70049464a879e0",
      "ontology/four_chamber_m1_manifest.py": "3f5ce12019c3680a52c5630efd0552cd3c166ce28fd244605ec2ef03b7190d8e",
      "simulation/_hybrid.py": "6c413537bbe91a2859bb612d488e54379d1462a023dfea2ca4eb319e3fb9cc77",
      "simulation/four_chamber_m1.py": "492c032ac03b6712db127a83e87b0b0109afdaa1c42c3c641f21793dcda9834c"
    }
  },
  "semantic_contract": {
    "compartments": {
      "la": {
        "anatomy": {
          "fma": "FMA:9465",
          "key": "la_cavity",
          "primary_id": "UBERON:0016513",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/4",
          "source_role_in_smith": "part of the pulmonary venous compartment blood (lumped)",
          "structure": "Cavity of left atrium",
          "uberon": "UBERON:0016513",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Separate M1 blood volume state.",
        "relation": "blood_contained_in",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_container"
        ]
      },
      "lv": {
        "anatomy": {
          "fma": "FMA:9466",
          "key": "lv_cavity",
          "primary_id": "UBERON:0016514",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/2",
          "source_role_in_smith": "container of LV blood (P_lv, V_lv)",
          "structure": "Cavity of left ventricle",
          "uberon": "UBERON:0016514",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Separate M1 blood volume state.",
        "relation": "blood_contained_in",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_container"
        ]
      },
      "pa": {
        "anatomy": {
          "fma": "FMA:52449",
          "key": "pulmonary_arterial_lumen",
          "primary_id": "FMA:52449",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/18",
          "source_role_in_smith": "container of the \"pulmonary artery\" compartment blood (P_pa, V_pa)",
          "structure": "Lumen of pulmonary arterial tree",
          "uberon": "UBERON:0002012",
          "uberon_relation": "related_structure"
        },
        "interpretation": "Anatomical context only; the lumen label is not identity with the whole lumped vascular bed.",
        "relation": "lumped_compartment_context",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_context"
        ]
      },
      "pv": {
        "anatomy": {
          "fma": "FMA:52455",
          "key": "pulmonary_venous_lumen",
          "primary_id": "FMA:52455",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/19",
          "source_role_in_smith": "with the LA cavity, container of the \"pulmonary vein\" compartment blood (P_pu, V_pu)",
          "structure": "Lumen of pulmonary venous tree organ",
          "uberon": "UBERON:0013127",
          "uberon_relation": "related_structure"
        },
        "interpretation": "Anatomical context only; the lumen label is not identity with the whole lumped vascular bed.",
        "relation": "lumped_compartment_context",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_context"
        ]
      },
      "ra": {
        "anatomy": {
          "fma": "FMA:11359",
          "key": "ra_cavity",
          "primary_id": "UBERON:0016522",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/5",
          "source_role_in_smith": "part of the systemic venous compartment blood (lumped)",
          "structure": "Cavity of right atrium",
          "uberon": "UBERON:0016522",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Separate M1 blood volume state.",
        "relation": "blood_contained_in",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_container"
        ]
      },
      "rv": {
        "anatomy": {
          "fma": "FMA:9291",
          "key": "rv_cavity",
          "primary_id": "UBERON:0016509",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/3",
          "source_role_in_smith": "container of RV blood",
          "structure": "Cavity of right ventricle",
          "uberon": "UBERON:0016509",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Separate M1 blood volume state.",
        "relation": "blood_contained_in",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_container"
        ]
      },
      "sa": {
        "anatomy": {
          "fma": "FMA:52448",
          "key": "systemic_arterial_lumen",
          "primary_id": "FMA:52448",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/16",
          "source_role_in_smith": "container of the \"aorta\" compartment blood (P_ao, V_ao): lumped systemic arteries (S6P p. 12-13)",
          "structure": "Lumen of systemic arterial tree",
          "uberon": "UBERON:0004571",
          "uberon_relation": "related_structure"
        },
        "interpretation": "Anatomical context only; the lumen label is not identity with the whole lumped vascular bed.",
        "relation": "lumped_compartment_context",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_context"
        ]
      },
      "sv": {
        "anatomy": {
          "fma": "FMA:52454",
          "key": "systemic_venous_lumen",
          "primary_id": "FMA:52454",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/17",
          "source_role_in_smith": "with the RA cavity, container of the \"vena cava\" compartment blood (P_vc, V_vc): lumped systemic veins",
          "structure": "Lumen of systemic venous tree organ",
          "uberon": "UBERON:0004581",
          "uberon_relation": "related_structure"
        },
        "interpretation": "Anatomical context only; the lumen label is not identity with the whole lumped vascular bed.",
        "relation": "lumped_compartment_context",
        "relationship_direction": [
          "modelled_blood",
          "anatomical_context"
        ]
      }
    },
    "edges": {
      "aortic": {
        "anatomy": {
          "fma": "FMA:7236",
          "key": "aortic_valve",
          "primary_id": "UBERON:0002137",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/7",
          "source_role_in_smith": "location of Q_av (E30)",
          "structure": "Aortic valve",
          "uberon": "UBERON:0002137",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Model flow located at v2 valve.",
        "kind": "diode",
        "relation": "flow_location",
        "relationship_direction": [
          "flow_process",
          "valve_location"
        ],
        "source": "lv",
        "target": "sa"
      },
      "mitral": {
        "anatomy": {
          "fma": "FMA:7235",
          "key": "mitral_valve",
          "primary_id": "UBERON:0002135",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/6",
          "source_role_in_smith": "location of Q_mt (E29)",
          "structure": "Mitral valve",
          "uberon": "UBERON:0002135",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Model flow located at v2 valve.",
        "kind": "diode",
        "relation": "flow_location",
        "relationship_direction": [
          "flow_process",
          "valve_location"
        ],
        "source": "la",
        "target": "lv"
      },
      "pulmonary": {
        "anatomy": null,
        "interpretation": "No dedicated v2 path node; project-local connection between the named compartments.",
        "kind": "resistor",
        "relation": "project_local_flow_path",
        "relationship_direction": [
          "pa",
          "pv"
        ],
        "source": "pa",
        "target": "pv"
      },
      "pulmonary_valve": {
        "anatomy": {
          "fma": "FMA:7246",
          "key": "pulmonary_valve",
          "primary_id": "UBERON:0002146",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/9",
          "source_role_in_smith": "location of Q_pv (E32)",
          "structure": "Pulmonary valve",
          "uberon": "UBERON:0002146",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Model flow located at v2 valve.",
        "kind": "diode",
        "relation": "flow_location",
        "relationship_direction": [
          "flow_process",
          "valve_location"
        ],
        "source": "rv",
        "target": "pa"
      },
      "pulmonary_venous": {
        "anatomy": null,
        "interpretation": "No dedicated v2 path node; project-local connection between the named compartments.",
        "kind": "resistor",
        "relation": "project_local_flow_path",
        "relationship_direction": [
          "pv",
          "la"
        ],
        "source": "pv",
        "target": "la"
      },
      "systemic": {
        "anatomy": null,
        "interpretation": "No dedicated v2 path node; project-local connection between the named compartments.",
        "kind": "resistor",
        "relation": "project_local_flow_path",
        "relationship_direction": [
          "sa",
          "sv"
        ],
        "source": "sa",
        "target": "sv"
      },
      "tricuspid": {
        "anatomy": {
          "fma": "FMA:7234",
          "key": "tricuspid_valve",
          "primary_id": "UBERON:0002134",
          "provenance": "docs/evidence_review/anatomy_nodes_v2.json#/nodes/8",
          "source_role_in_smith": "location of Q_tc (E31)",
          "structure": "Tricuspid valve",
          "uberon": "UBERON:0002134",
          "uberon_relation": "same_structure_v2_xref"
        },
        "interpretation": "Model flow located at v2 valve.",
        "kind": "diode",
        "relation": "flow_location",
        "relationship_direction": [
          "flow_process",
          "valve_location"
        ],
        "source": "ra",
        "target": "rv"
      },
      "venous_return": {
        "anatomy": null,
        "interpretation": "No dedicated v2 path node; project-local connection between the named compartments.",
        "kind": "resistor",
        "relation": "project_local_flow_path",
        "relationship_direction": [
          "sv",
          "ra"
        ],
        "source": "sv",
        "target": "ra"
      }
    },
    "evidence_status": {
      "extracted_facts": "Identifiers, labels and Smith roles copied from project-owned v2.",
      "interpretation": "M1 topology, gauge and mappings are software design assertions, not ontology entailments.",
      "verbatim_evidence": "Not reproduced here; see v2 source pointers."
    },
    "metric_aliases": {
      "lv_cardiac_output_ml_s": "CO_lv",
      "lv_stroke_volume_ml": "SV_lv",
      "rv_cardiac_output_ml_s": "CO_rv",
      "rv_stroke_volume_ml": "SV_rv"
    },
    "model_id": "four_chamber_m1",
    "model_version": "1.0.0",
    "parameter_contract": {
      "compliance_pa": {
        "order": null,
        "property": "https://example.org/physiosim/concept/fluid_volume_compliance",
        "property_source": "project-local model definition",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mL/mmHg"
      },
      "compliance_pv": {
        "order": null,
        "property": "https://example.org/physiosim/concept/fluid_volume_compliance",
        "property_source": "project-local model definition",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mL/mmHg"
      },
      "compliance_sa": {
        "order": null,
        "property": "https://example.org/physiosim/concept/fluid_volume_compliance",
        "property_source": "project-local model definition",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mL/mmHg"
      },
      "compliance_sv": {
        "order": null,
        "property": "https://example.org/physiosim/concept/fluid_volume_compliance",
        "property_source": "project-local model definition",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mL/mmHg"
      },
      "elastance_la": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "elastance_ra": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "emax_lv": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "emax_rv": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "emin_lv": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "emin_rv": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00076",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg/mL"
      },
      "heart_rate": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_01212",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "1/min"
      },
      "initial_volumes": {
        "order": [
          "lv",
          "sa",
          "sv",
          "ra",
          "rv",
          "pa",
          "pv",
          "la"
        ],
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "initial",
        "unit": "mL"
      },
      "resistance_aortic": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_mitral": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_pulmonary": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_pulmonary_valve": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_pulmonary_venous": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_systemic": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_tricuspid": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "resistance_venous_return": {
        "order": null,
        "property": "http://bhi.washington.edu/OPB#OPB_00160",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mmHg*s/mL"
      },
      "systolic_fraction": {
        "order": null,
        "property": "https://example.org/physiosim/concept/systolic_fraction",
        "property_source": "project-local M1 definition",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "dimensionless"
      },
      "unstressed_volumes": {
        "order": [
          "lv",
          "sa",
          "sv",
          "ra",
          "rv",
          "pa",
          "pv",
          "la"
        ],
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "Required explicit caller input; no literature-derived default or calibration.",
        "temporal": "constant_parameter",
        "unit": "mL"
      }
    },
    "pressure_reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
    "source": {
      "canonical_json_sha256": "0e9296ffa439b7ff0e2f6eb51a04a231ea65a1b2b0640b1a0e10d838bdd7a841",
      "ontology_versions": {
        "fma": "5.1.0 (2026-05-15, uw-sig/FMA), CC BY 4.0, OBO inactive",
        "uberon": "2026-10-01 (http://purl.obolibrary.org/obo/uberon/releases/2026-10-01/uberon.owl), CC BY 3.0, OBO active"
      },
      "path": "docs/evidence_review/anatomy_nodes_v2.json",
      "validation_scope": "Checked against project-owned v2; no new external source validation.",
      "version": "Anatomical node specification v2 (2026-11-01)"
    },
    "unresolved_conflicts": [
      "v2 la_cavity/ra_cavity roles describe Smith lumped venous blood; M1 uses separate states. No legacy identity or volume split is asserted.",
      "v2 pulmonary_venous_lumen records UBERON:0013127 as related structure with no FMA xref; FMA:52455 is the primary lumen identifier."
    ],
    "variables": {
      "CO_lv": {
        "bearer": "flow_process",
        "compartment": "lv",
        "direction": [
          "lv",
          "sa"
        ],
        "edge": "aortic",
        "kind": "cardiac_output",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "mL/s"
      },
      "CO_rv": {
        "bearer": "flow_process",
        "compartment": "rv",
        "direction": [
          "rv",
          "pa"
        ],
        "edge": "pulmonary_valve",
        "kind": "cardiac_output",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "mL/s"
      },
      "P_la": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "chamber_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_lv": {
        "bearer": "blood",
        "compartment": "lv",
        "direction": null,
        "edge": null,
        "kind": "chamber_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_pa": {
        "bearer": "blood",
        "compartment": "pa",
        "direction": null,
        "edge": null,
        "kind": "compartment_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_pv": {
        "bearer": "blood",
        "compartment": "pv",
        "direction": null,
        "edge": null,
        "kind": "compartment_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_ra": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "chamber_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_rv": {
        "bearer": "blood",
        "compartment": "rv",
        "direction": null,
        "edge": null,
        "kind": "chamber_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_sa": {
        "bearer": "blood",
        "compartment": "sa",
        "direction": null,
        "edge": null,
        "kind": "compartment_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "P_sv": {
        "bearer": "blood",
        "compartment": "sv",
        "direction": null,
        "edge": null,
        "kind": "compartment_pressure",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "instantaneous",
        "unit": "mmHg"
      },
      "Q_aortic": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "lv",
          "sa"
        ],
        "edge": "aortic",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_cum_aortic": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "lv",
          "sa"
        ],
        "edge": "aortic",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_mitral": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "la",
          "lv"
        ],
        "edge": "mitral",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_pulmonary": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "pa",
          "pv"
        ],
        "edge": "pulmonary",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_pulmonary_valve": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "rv",
          "pa"
        ],
        "edge": "pulmonary_valve",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_pulmonary_venous": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "pv",
          "la"
        ],
        "edge": "pulmonary_venous",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_systemic": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "sa",
          "sv"
        ],
        "edge": "systemic",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_tricuspid": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "ra",
          "rv"
        ],
        "edge": "tricuspid",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_cum_venous_return": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "sv",
          "ra"
        ],
        "edge": "venous_return",
        "kind": "cumulative_transported_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "run_integrated",
        "unit": "mL"
      },
      "Q_mitral": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "la",
          "lv"
        ],
        "edge": "mitral",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_pulmonary": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "pa",
          "pv"
        ],
        "edge": "pulmonary",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_pulmonary_valve": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "rv",
          "pa"
        ],
        "edge": "pulmonary_valve",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_pulmonary_venous": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "pv",
          "la"
        ],
        "edge": "pulmonary_venous",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_systemic": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "sa",
          "sv"
        ],
        "edge": "systemic",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_tricuspid": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "ra",
          "rv"
        ],
        "edge": "tricuspid",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "Q_venous_return": {
        "bearer": "flow_process",
        "compartment": null,
        "direction": [
          "sv",
          "ra"
        ],
        "edge": "venous_return",
        "kind": "flow",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL/s"
      },
      "SV_lv": {
        "bearer": "flow_process",
        "compartment": "lv",
        "direction": [
          "lv",
          "sa"
        ],
        "edge": "aortic",
        "kind": "forward_stroke_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_integrated",
        "unit": "mL"
      },
      "SV_rv": {
        "bearer": "flow_process",
        "compartment": "rv",
        "direction": [
          "rv",
          "pa"
        ],
        "edge": "pulmonary_valve",
        "kind": "forward_stroke_volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_integrated",
        "unit": "mL"
      },
      "V_la": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_lv": {
        "bearer": "blood",
        "compartment": "lv",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_pa": {
        "bearer": "blood",
        "compartment": "pa",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_pv": {
        "bearer": "blood",
        "compartment": "pv",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_ra": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_rv": {
        "bearer": "blood",
        "compartment": "rv",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_sa": {
        "bearer": "blood",
        "compartment": "sa",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "V_sv": {
        "bearer": "blood",
        "compartment": "sv",
        "direction": null,
        "edge": null,
        "kind": "volume",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "instantaneous",
        "unit": "mL"
      },
      "la_pressure_max_mmhg": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "la_pressure_mean_mmhg": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_mean",
        "unit": "mmHg"
      },
      "la_pressure_min_mmhg": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "la_volume_max_ml": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "la_volume_mean_ml": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "mL"
      },
      "la_volume_min_ml": {
        "bearer": "blood",
        "compartment": "la",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "lv_cardiac_output_l_min": {
        "bearer": "flow_process",
        "compartment": "lv",
        "direction": [
          "lv",
          "sa"
        ],
        "edge": "aortic",
        "kind": "cardiac_output",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "L/min"
      },
      "lv_edv_sample_ml": {
        "bearer": "blood",
        "compartment": "lv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_extremum",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "lv_ejection_fraction_sample": {
        "bearer": "blood",
        "compartment": "lv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_excursion_fraction",
        "property": "https://example.org/physiosim/concept/volume_excursion_fraction",
        "property_source": "project-local M1 definition",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "dimensionless"
      },
      "lv_esv_sample_ml": {
        "bearer": "blood",
        "compartment": "lv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_extremum",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "pa_pressure_max_mmhg": {
        "bearer": "blood",
        "compartment": "pa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "pa_pressure_mean_mmhg": {
        "bearer": "blood",
        "compartment": "pa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_mean",
        "unit": "mmHg"
      },
      "pa_pressure_min_mmhg": {
        "bearer": "blood",
        "compartment": "pa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "ra_pressure_max_mmhg": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "ra_pressure_mean_mmhg": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_mean",
        "unit": "mmHg"
      },
      "ra_pressure_min_mmhg": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "ra_volume_max_ml": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "ra_volume_mean_ml": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "mL"
      },
      "ra_volume_min_ml": {
        "bearer": "blood",
        "compartment": "ra",
        "direction": null,
        "edge": null,
        "kind": "volume_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "rv_cardiac_output_l_min": {
        "bearer": "flow_process",
        "compartment": "rv",
        "direction": [
          "rv",
          "pa"
        ],
        "edge": "pulmonary_valve",
        "kind": "cardiac_output",
        "property": "http://bhi.washington.edu/OPB#OPB_00299",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_mean",
        "unit": "L/min"
      },
      "rv_edv_sample_ml": {
        "bearer": "blood",
        "compartment": "rv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_extremum",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "rv_ejection_fraction_sample": {
        "bearer": "blood",
        "compartment": "rv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_excursion_fraction",
        "property": "https://example.org/physiosim/concept/volume_excursion_fraction",
        "property_source": "project-local M1 definition",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "dimensionless"
      },
      "rv_esv_sample_ml": {
        "bearer": "blood",
        "compartment": "rv",
        "direction": null,
        "edge": null,
        "kind": "sampled_volume_extremum",
        "property": "http://bhi.washington.edu/OPB#OPB_00154",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "not applicable",
        "temporal": "beat_sample_extremum",
        "unit": "mL"
      },
      "sa_pressure_max_mmhg": {
        "bearer": "blood",
        "compartment": "sa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      },
      "sa_pressure_mean_mmhg": {
        "bearer": "blood",
        "compartment": "sa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_mean",
        "unit": "mmHg"
      },
      "sa_pressure_min_mmhg": {
        "bearer": "blood",
        "compartment": "sa",
        "direction": null,
        "edge": null,
        "kind": "pressure_summary",
        "property": "http://bhi.washington.edu/OPB#OPB_00509",
        "property_source": "https://raw.githubusercontent.com/SemBioProcess/SemGen/master/src/semsim/owl/OPBv1.07.owl",
        "provenance": "docs/physiology_four_chamber_m1.md#equations-and-contract",
        "reference": "model gauge pressure relative to one common fixed external pressure of 0 mmHg; no intrathoracic/pericardial pressure",
        "temporal": "beat_sample_extremum",
        "unit": "mmHg"
      }
    }
  }
}